Javascript Unit test

I have a javascript app within 250 lines and want to add tests to that. Whenever i make a tiny change, i have to run tests for atleast 10 cases manually, which i want to automate.

I could have gone for frameworks as suggested in different posts, but the solution i want is minimum friction and codebase. Something like a single file for unit testing may work.

Is there a way for using JS testing without any frameworks ? I want to write Unit tests / functional tests both. Or if Frameworks is the only option, what frameworks are preferred in terms os ease of plugin to existing code + learning curve.