Best automation tool for testing desktop based PLM system?

Which one is best automation tool for testing desktop based PLM system? At first let me share my search result, what I have found after Googling.

Teamcenter PLM Testing Services: Not inserted as there are provide there own service.

Open source tools for testing desktop based app:

-Robot Framework with Sikuli library

-Pywinauto

-Auto IT

-Winium (Selenium)

Question 1: Which one will be best among above list, is there anything else?

Question 2: Is there any paid tools for automation desktop based PLM app?(If yes, name please)

Please share your personal experience