Sybase ASE 16 upgrade Test Approach

I will be working as QA on a projects which is upgrading Sybase ASE to version 16. I have not worked on RDBMS system upgrade projects before. I need assistance in drafting a Test strategy. Could anyone please provide me guidance on - What are the Steps involved in upgrading Sybase ASE version - From System test point of view what sorts of test should we be running (We are already running regression on the applications which are connected to the DBs but apart from that what else should we be validating?)