What will be the best tool to automate a Single Page Application test cases

I have a new website to test which is a Single page application (SPA) and I'm not sure which tool shall I use to automate it. I thought of Selenium and Protractor but Protractor would not be a good idea as my site has nothing to do with AngularJS and in that case is it like Selenium WebDriver is the only option or there are any other tool available in market? If selenium is the only good option then what sort of challenge I can face?